preparation and evaluation of poly (caprolactone fumarate) nanoparticles containing doxorubicin hcl

Preparation and evaluation of poly (caprolactone fumarate) nanoparticles containing doxorubicin HCI

BACKGROUND AND THE PURPOSE OF THE STUDY Biodegradable Poly(caprolactone fumarate) (PCLF) has been used as bioresorbable sutures. In this study, doxorubicin HCl (Dox) loaded PCLF nanoparticles were prepared and characterized. MATERIAL AND METHODS PCLFs were synthesized by polycondensation of PCL diols (Mws of 530, 1250 and 2000) with fumaryl chloride. The degradation of PCLF in NaOH, water and...

Preparation and Evaluation of Poly (s-caprolactone) Nanoparticles-in- Microparticles by W/O/W Emulsion Method

Objective(s) Theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. It is used both as a prophylactic drug and to prevent acute exacerbations of asthma. The aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release. Materials and Me...

Chitosan-poly (lactide-co-glycolide) (CS-PLGA) nanoparticles containing metformin HCl: preparation and in vitro evaluation.

In this study, the preparation and in vitro characterisation of metformin HCl-loaded CS-PLGA nanoparticles (NPs) were aimed. The prepared nanoparticles (blank nanoparticles (C-1), 50 mg of metformin HCl loaded nanoparticles (C-2) and 75 mg of metformin HCl loaded nanoparticles (C-3) ranged in size from 506.67±13.61 to 516.33±16.85 nm and had surface charges of 22.57±1.21 to 32.37±0.57 mV. Low e...

In Vitro and in Vivo Evaluation of Poly (caprolactone Fumarate) Nanoparticles

N. Shokri 1, , E. Azizi , H. Akbari Javar 1, , Sh. Fouladdel , A. Khalaj 3 and R. Dinarvand 1, 4 Department of Pharmaceutics , Faculty of pharmacy, Tehran University of Medical Sciences, Tehran, Iran Molecular Research Lab , Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Medicinal Chemistry , Faculty of Pharmacy,...

preparation and characterization of poly(e-caprolactone)–poly(ethylene glycol) – poly(e-caprolactone) nanoparticles for sustained release of tamoxifen

Preparation and Evaluation of Poly (ε-caprolactone) Nanoparticles-in- Microparticles by W/O/W Emulsion Method

Objective(s) Theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. It is used both as a prophylactic drug and to prevent acute exacerbations of asthma. The aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release. Materials and Me...